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By adjusting a single free parametera constant antigen concentration C ( t ) = C exp our model accurately captures the dynamics of affinity gain, reproducing the characteristic rapid initial rise followed by a slower improvement observed in vivo

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Because it is driven by repetitive hand and wrist use, it is frequently seen in people whose work or hobbies involve gripping or repetitive motion, including painters, plumbers, carpenters, mechanics, butchers, cooks, musicians, and office workers who spend long hours typing or using a computer mouse